ŚLĄZAK Błażej

PhD in biology: Faculty of Biology and Earth Sciences, Jagiellonian University (2014)

MSc in biology: Interdisciplinary Studies of Mathematical and Natural Sciences, Jagiellonian University (2008)


(updated: March 2019)

Research experience:

  • March 2015 - present - Department of Ecology, W. Szafer Institute of Botany, Polish Academy of Science
  • January - February and June 2015 - Division of Pharmacognosy, Department of Medicinal Chemistry, Uppsala University,
  • October 2009 – December 2014 - Department of Plant Cytology and Embryology, Institute of Botany, Faculty of Biology and Earth Sciences, Jagiellonian University,
  • June 2010 – September 2013 - Arcana Institute LTD, LA-SER International Group
Research topics:

IIn my work I am trying to bring together various natural sciences disciplines. My field of interest concerns on the interdisciplinary science of chemical ecology, linking together biology, biochemistry and ecology. I'm interested in plant defense mechanisms mediated through defense metabolites and the role they play in complex interactions between the plant, pathogens and environment.

Currently I work with cyclotides, peptides characterized by a circular peptide backbone and a cystine knot motif. This signature motif gives extreme stability that can harness a wide spectrum of biological activities, with implications in plant defense and with applications in medicine and biotechnology. In my work, I am aiming to gain a deeper insight into cyclotides role in defense mechanisms.

My main research tools are different types of chromatography methods, mass spectrometry, plant cell cultures, immunohistochemistry and transcriptomics.

Grants and scholarships:
  • Regnells Foundation travel grant (Faculty of Pharmacy, Uppsala University)
  • SONATA National Science Center (NCN) grant (registration number: 2017/26/D/NZ8/00658)
  • MINIATURA NCN grant (registration number 2017/01/X/NZ8/00606)
  • Tryggers Foundation 6 months post doc scholarship (Faculty of Pharmacy, Uppsala University)
  • Polish Academy of Sciences grant for young researchers in the Institute of Botany of PAS (2015 and 2017 editions)
  • Ahlquist Foundation grants for research exchange (Faculty of Pharmacy, Uppsala University)
  • Erazmus Practice scholarship for research practice at Uppsala University (May - July 2013)
  • Dean of the Faculty of Biology and Earth Sciences of Jagiellonian University research grants
  • Jagiellonian University PhD student scholarship (2009 - 2013)
 Adress:
  Department of Ecology, W. Szafer Institute of Botany, Polish Academy of Sciences, Lubicz 46, PL 31-512 Kraków,
Phone, fax:   (+48) 12-42-41-742, fax: (+48) 12-421-97-90,
e-mail:
  b.slazak@botany.pl


Most important publications:







Journal Publications:

Slazak B, Kapusta M, Strömstedt AA, Słomka A, Krychowiak M, Shariatgorji M, Andrén PE, Bohdanowicz J, Kuta E, Göransson U. 2018. How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests – Cyclotides as a Comprehensive Plant Host Defense System. Front. Plant Sci. 9.

Uddin SJ, Muhammad T, Shafiullah M, Slazak B, Rouf R, Göransson U. 2017. Single-step purification of cyclotides using affinity chromatography. Biopolymers 108:1–8.

Slazak B, Kapusta M, Malik S, Bohdanowicz J, Kuta E, Malec P, Göransson U. 2016. Immunolocalization of cyclotides in plant cells, tissues and organ supports their role in host defense. Planta 244:1029–1040

Göransson U, Malik S, Slazak B. 2015. Cyclotides in the Violaceae. Advances in Botanical Research 76: 15-49. DOI:10.1016/bs.abr.2015.09.001

Slazak B, Jacobsson E, Kuta E, Göransson U. 2015. Exogenous plant hormones and cyclotide expression in Viola uliginosa (Violaceae). Phytochemistry 117:527-536. DOI:10.1016/j.phytochem.2015.07.016

Slazak B, Sliwinska E, Saluga M, Ronikier M, Bujak J, Slomka A, Goransson U, Kuta E. 2015. Micropropagation of Viola uliginosa (Violaceae) for endangered species conservation and for somaclonal variation-enhanced cyclotide biosynthesis. Plant Cell Tissue and Organ Culture 120(1): 179-190. DOI:10.1007/s11240-014-0592-3

Selected conference proceedings:

Jacobsson E, Slazak B, Kuta E, Göransson U: Cyclotide mining in callus tissue culture and wild type transcriptomes of Viola uliginosa. 24th American Peptide Symposium June 20-25, Orlando, USA; 06/2015

Ślązak B, Kapusta M, Malik S, Bohdanowicz J, Kuta E, Malec P, Göransson U: Immunolocalization of cyclotides in plant cell, tissue and organs supports their role in plant defense. Nordic Natural Products Conference June 14-16, 2015,, Visby, Sweden; 06/2015

Żabicki P, Ślązak B, Tuleja M, Malec P, Kuta E: Histology, H istoc H emistry and sem are useful tools to study regeneration processes in plant tissue culture. Modern Phytomorphology; 01/2013

Walczak J, Lipińska M, Jarosz J, Moczyński W, Ślązak B, Laczewski T: PSY2. Clinical Effectiveness Analysis of Deferasirox for the Treatment of Iron Overload Due to Frequent Blood Transfusions. Value in Health; 11/2013

Shergill S, Miasek B, Borowiack M, Czarny-Ozga I, Moczynski W, Stelmachowski J, Slazak B, Wachal M: DGI-075 Use of Botulinum Toxin Type A in Poland: Systematic Review and Questionnaire Survey. European Journal of Hospital Pharmacy: Science and Practice; 03/2013

Ślązak B, Bujak J, Göransson U, Kuta E: Micropropagation protocol of Viola uliginosa, species threatened with extinction and cyclotide content in plants from natural sites and in material from in vitro culture. The 10th International Ph.D. Student Conference on Experimental Plant Biology,  3rd - 5th September 2012, Brno, Czech Republic

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